Please use this identifier to cite or link to this item: http://dl.merc.ac.ir/handle/Hannan/36500
Title: Complete Genes May Pass from Food to Human Blood
Authors: Spisák, Sándor
Solymosi, Norbert
Ittzés, Péter
Bodor, András
Kondor, Dániel
Vattay, Gábor
Barták, Barbara K.
Sipos, Ferenc
Galamb, Orsolya
Tulassay, Zsolt
Szállási, Zoltán
Rasmussen, Simon
Sicheritz-Ponten, Thomas
Brunak, Søren
Molnár, Béla
Csabai, István
Keywords: Biology;Anatomy and Physiology;Digestive System;Digestive Physiology;Digestive Functions;Genomics;Genome Analysis Tools;Genome Scans;Genome-Wide Association Studies;Comparative Genomics;Genome Sequencing;Metagenomics
Issue Date: 2013
Publisher: Public Library of Science
Description: Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. The plant DNA concentration shows a surprisingly precise log-normal distribution in the plasma samples while non-plasma (cord blood) control sample was found to be free of plant DNA.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728338/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11855913
Other Identifiers: Spisák, S., N. Solymosi, P. Ittzés, A. Bodor, D. Kondor, G. Vattay, B. K. Barták, et al. 2013. “Complete Genes May Pass from Food to Human Blood.” PLoS ONE 8 (7): e69805. doi:10.1371/journal.pone.0069805. http://dx.doi.org/10.1371/journal.pone.0069805.
1932-6203
Appears in Collections:HMS Scholarly Articles

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