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|Title:||Ugi Four-Component Reaction with Tandem Deprotection, Cyclization and Pictet–Spengler Reaction: A Concise Route to N-Fused Polycyclic Indolediketopiperazine Alkaloid Analogues|
Chauhan, P M S
|Keywords:||Indolediketopiperazine alkaloids;Ugi-multicomponent reaction;Tandem reaction;Deprotection-cyclization reactions;Pictet-Spengler reaction|
|Description:||Aza-fused polycyclic indolediketopiperazine alkaloids are of potential interest due to their broad range of biological activities. Traditionally, a number of methods have been reported to generate N-fused polycyclic indolediketopiperazine skeletons, but the development of novel, concise methods to modify its substitution pattern are strongly required. Herein, we have described the two-step formation of N-fused polycyclic indolediketopiperazine alkaloid analogues by the application of the Ugi 4-CR with tandem deprotection-cyclization/Pictet-Spengler reaction|
|Other Identifiers:||Synlett, 2013, 24 (10), 1291-1297|
|Appears in Collections:||Medicinal and Process Chemistry|
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