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Title: Ugi Four-Component Reaction with Tandem Deprotection, Cyclization and Pictet–Spengler Reaction: A Concise Route to N-Fused Polycyclic Indoledi­ketopiperazine Alkaloid Analogues
Authors: Tyagi, Vikas
Khan, Shahnawaz
Chauhan, P M S
Keywords: Indolediketopiperazine alkaloids;Ugi-multicomponent reaction;Tandem reaction;Deprotection-cyclization reactions;Pictet-Spengler reaction
Issue Date: 2013
Description: Aza-fused polycyclic indolediketopiperazine alkaloids are of potential interest due to their broad range of biological activities. Traditionally, a number of methods have been reported to generate N-fused polycyclic indolediketopiperazine skeletons, but the development of novel, concise methods to modify its substitution pattern are strongly required. Herein, we have described the two-step formation of N-fused polycyclic indolediketopiperazine alkaloid analogues by the application of the Ugi 4-CR with tandem deprotection-cyclization/Pictet-Spengler reaction
Other Identifiers: Synlett, 2013, 24 (10), 1291-1297
Appears in Collections:Medicinal and Process Chemistry

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