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Title: Base mediated 7-exo-dig intramolecular cyclization of Ugi-Propargyl precursors: Ugi-Propargyl precursors and regioselective synthetic approach toward diverse 1, 4-benzoxazepine-5(2H)-ones
Authors: Pandey, Shashi
Kumar, S V
Kant, Ruchir
Chauhan, P M S
Keywords: Base Mediated 7-Exo-Dig;Intramolecular Cyclization;Ugi-Propargyl Precursors;Ugi-Propargyl Precursors;Regioselective Synthetic Approach
Issue Date: 2014
Description: A metal-free facile and efficient two-step synthetic protocol for the preparation of 1, 4-benzoxazepine-5(2H)-ones derivatives has been developed. The protocol involves Ugi reaction followed by K2CO3 mediated highly regioselective 7-exo-dig intramolecular cyclization of less-nucleophilic oxygen with the pendant alkyne moiety of Ugi-propargyl precursor to afford the 1, 4-benzoxazepine-5(2H)-one derivatives in good to excellent yields.
Other Identifiers: Organic & Biomolecular Chemistry, 2014, 12, 5346-5350
Appears in Collections:Medicinal and Process Chemistry

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