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Title: Amino Acid and Water-Driven Tunable Green Protocol to Access S-S/C-S Bonds via Aerobic Oxidative Coupling and Hydrothiolation
Authors: Shard, Amit
Kumar, Rajesh
Sharma, Nidhi
Sinha, A K
Keywords: Amino acids;Oxidative coupling;Vinyl sulfides;Waste-free
Issue Date: 2014
Description: A green methodology utilizing natural auxiliary like L-Arginine in conjunction with water and oxygen led to oxidative coupling of thiols into disulfides (S-S bond) whereas thiol-yne coupling (TYC) to access vinyl sulfides (C-S bond) was facilitated in nitrogen atmosphere. The tunable protocol offers several advantages like low catalyst loading, high yields, clean reaction, no over-oxidation of S-S bond besides being metal/base/waste-free. The synthesis of ubiquitous cystine and GSSG in the same catalytic system is an added advantage and the catalytic system has been recycled up to seven times.
Other Identifiers: RSC Advances, 2014, 4(63), 33399-33407
Appears in Collections:Medicinal and Process Chemistry

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