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Title: New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents
Authors: Chauhan, Kuldeep
Sharma, Moni
Trivedi, Priyanka
Chaturvedi, Vinita
Chauhan, P. M. S.
Keywords: Rhodanine;Tetrazole;Mycobacterium tuberculosis;Cytotoxicity
Issue Date: 2014
Description: In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, four compounds (10, 14, 20 and 33) exhibited more potent activity (MIC = 3.08, 3.01, 2.62 and 2.51 μM) than ethambutol (MIC = 9.78 μM) and pyrazinamide (MIC = 101.53 μM) against Mycobacterium tuberculosis. Furthermore, they displayed no toxicity against Vero cells (C1008) and mouse bone marrow derived macrophages (MBMDMɸ). These investigated analogues have emerged as possible lead molecule to enlarge the scope of the study.
Other Identifiers: Bioorganic & Medicinal Chemistry Letters, 2014, 24 (17), 4166–4170
Appears in Collections:Medicinal and Process Chemistry

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