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Title: Efficient Stereocontrolled Synthesis of Sitagliptin Phosphate
Authors: Subbaiah, C S
Haq, W
Keywords: Sitagliptin phosphate;Type 2 diabetes mellitus;Stereocontrolled alkylation;Asymmetric synthesis
Issue Date: 2014
Description: Synthesis of sitagliptin phosphate 1, a novel DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been accomplished starting from chiral synthon (1,4-bis[(R)-1-phenylethyl]piperazine-2,5-dione) 2, involving high stereocontrolled (>98%) alkylation as a key step, in a good overall yield of 50% over six steps.
Other Identifiers: Tetrahedron: Asymmetry,2014, 25(13–14), 1026–1030
Appears in Collections:Medicinal and Process Chemistry

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