Please use this identifier to cite or link to this item: http://dl.merc.ac.ir/handle/Hannan/52931
Title: Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity
Authors: Reddy, P V
Saquib, Mohammad
Mishra, N N
Shukla, P K
Shaw, A K
Keywords: THF alkynes;THF azides;C-nucleosides;‘click’ chemistry;1,2,3-triazoles
Issue Date: 2014
Description: The construction of a novel series of enantiopure tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues utilizing click reaction of sugar derived tetrahydrofuranyl alkynes with various ‘in house’ synthesized sugar derived tetrahydrofuranyl azides and an adamantyl azide is described. The biological significance of the synthesized C-nucleosides was highlighted by evaluating them in vitro for anti-bacterial and anti-fungal activity wherein a number of compounds were found to show excellent anti-bacterial activity and moderate anti-fungal activity.
URI: http://hdl.handle.net/123456789/1421
Other Identifiers: Arkivoc, 2014, 2014 (iv), 170-182
Appears in Collections:Medicinal and Process Chemistry

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